What is vastarel mr 35 mg used for

When you take this medication regularly on a long term basis, it can help treat angina by reducing the number of times you get angina. Do not stop taking your medication without checking with your healthcare professional. If you stop taking your medication, you may experience a worsening of your condition. If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Then take your next dose at the usual time.

Do not take two doses to make up for the missed dose. You are taking any other medications, including supplements, traditional medications and herbal remedies. Inform your healthcare professional if these side-effects do not go away and are affecting your daily life.

Very rarely, trimetazidine may cause movement disturbances. These symptoms may include one or more of the following:. If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately. Store in a cool and dry place, away from direct sunlight. No significant difference between groups could be found for the other secondary endpoints total exercise duration, total workload and clinical endpoints.

In the overall population, including both asymptomatic and symptomatic patients, trimetazidine failed to demonstrate a benefit on both ergometric total exercise duration, time to onset of 1mm ST and time to onset angina and clinical endpoints. Pharmacokinetics: After oral administration, maximum concentration is found, on average, 5 hours after taking the tablet.

Steady state is reached by the 60 th hour, at the latest. The pharmacokinetic characteristics of Vastarel 35mg are not influenced by meals. The apparent distribution volume is 4. Trimetazidine is eliminated primarily in the urine, mainly in the unchanged form. The elimination half-life of Vastarel 35mg is an average of 7 hours in healthy young volunteers and 12 hours in subjects aged more than 65 years.

Total clearance of trimetazidine is the result of major renal clearance which is directly correlated to creatinine clearance and, to a lesser extent, to liver clearance which is reduced with age. Special populations: Elderly subjects: A specific clinical study carried out in an elderly population using a dosage of 2 tablets per day taken in 2 doses, analysed by a population pharmacokinetics approach, showed an increase in plasma exposure.

The elderly may have increased trimetazidine exposure due to age-related decrease in renal function. Renal impairment: Trimetazidine exposure is increased on average by 1.

No safety concerns were observed in this population as compared with the general population. Toxicology: Preclinical safety data: Chronic toxicity studies conducted by the oral route in dogs and rats, showed a good safety profile.

The genotoxic potential was assessed in in vitro studies, including evaluation of the mutagenic and clastogenic potential, and one in vivo study. All the tests were negative. Reproductive toxicity studies in mice, rabbits and rats showed no embryotoxicity or teratogenicity. In rats, fertility was not impaired and there was no effects on postnatal development. Trimetazidine is indicated in adults as add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line antianginal therapies.

Dosage: Oral route. The dose is one tablet of trimetazidine 35 mg twice daily, i. The benefit of the treatment should be assessed after three months and trimetazidine should be discontinued if there is no treatment response. Elderly patients: Elderly patients may have increased trimetazidine exposure due to age-related decrease in renal function see Pharmacology: Pharmacokinetics under Actions.

Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Vastarel MR Tablet , please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.

Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar condition s. This may lead to overdosage. Please consult your physician or pharmacist or product package for more information.

Do not freeze medicines unless required by package insert. Keep medicines away from children and pets. Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Vastarel MR Tablet.

However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drugs. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.

Dosage Information Please consult your physician or pharmacist or refer to the product package. Cite this page Page URL. Accessed July 22, Vastarel MR Tablet causing itchy skin rash? What are the uses of Vastarel MR Tablet? What are the side-effects of Vastarel MR Tablet? What other medicines does Vastarel MR Tablet interact with?

When should you not use Vastarel MR Tablet? What precautions should you take while using Vastarel MR Tablet? Sign Up. Continue with Email. Invite your friends to TabletWise learning marketplace.